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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CFTR All Species: 25.15
Human Site: Y304 Identified Species: 50.3
UniProt: P13569 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P13569 NP_000483.3 1480 168142 Y304 R K A A Y V R Y F N S S A F F
Chimpanzee Pan troglodytes Q2QLE5 1480 168220 Y304 R K A A Y V R Y F N S S A F F
Rhesus Macaque Macaca mulatta NP_001028110 1481 168436 Y304 R K A A Y V R Y F N S S A F F
Dog Lupus familis XP_542642 1516 170242 C278 L T K A I I K C Y W K S Y L V
Cat Felis silvestris
Mouse Mus musculus P26361 1476 167852 F304 R K A A Y M R F F T S S A F F
Rat Rattus norvegicus P34158 1476 167812 F304 R R S A Y M R F F T S S A F F
Wallaby Macropus eugenll
Platypus Ornith. anatinus Q07DZ6 1484 168832 Y304 R K A A Y M R Y F N S S A F F
Chicken Gallus gallus Q5F364 1525 170953 R270 K E W A K T K R Q P L N M L Y
Frog Xenopus laevis P26363 1485 168877 Y305 R K A A Y V R Y F N S S A F F
Zebra Danio Brachydanio rerio NP_001038348 1485 168381 Y305 R K I G S L R Y F Y S S A Y F
Tiger Blowfish Takifugu rubipres NP_001041505 1511 170002 Y305 R K I G Y L R Y F Y S A A Y F
Fruit Fly Dros. melanogaster P91660 1290 143990 D177 L T K G A L G D T T S G H V V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.1 23.6 N.A. 78.5 78 N.A. 83.3 20.6 77.3 55.7 58.7 28.3 N.A. N.A. N.A.
Protein Similarity: 100 99.8 98.9 44.2 N.A. 88.7 88.1 N.A. 92.3 41.3 88.3 75.5 76.4 50.4 N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 80 66.6 N.A. 93.3 6.6 100 60 60 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 33.3 N.A. 93.3 93.3 N.A. 100 40 100 73.3 80 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 50 75 9 0 0 0 0 0 0 9 75 0 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 17 75 0 0 0 0 59 75 % F
% Gly: 0 0 0 25 0 0 9 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 17 0 9 9 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 67 17 0 9 0 17 0 0 0 9 0 0 0 0 % K
% Leu: 17 0 0 0 0 25 0 0 0 0 9 0 0 17 0 % L
% Met: 0 0 0 0 0 25 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 42 0 9 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 75 9 0 0 0 0 75 9 0 0 0 0 0 0 0 % R
% Ser: 0 0 9 0 9 0 0 0 0 0 84 75 0 0 0 % S
% Thr: 0 17 0 0 0 9 0 0 9 25 0 0 0 0 0 % T
% Val: 0 0 0 0 0 34 0 0 0 0 0 0 0 9 17 % V
% Trp: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 0 % W
% Tyr: 0 0 0 0 67 0 0 59 9 17 0 0 9 17 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _